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Comment
. 2008 Apr;73(8):903-5.
doi: 10.1038/ki.2008.69.

Connecting the interpodocyte slit diaphragm and actin dynamics: Emerging role for the nephrin signaling complex

S Lehtonen  1
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Free article
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Connecting the interpodocyte slit diaphragm and actin dynamics: Emerging role for the nephrin signaling complex

S Lehtonen. Kidney Int. 2008 Apr.
Free article

Abstract

Uchida et al. show in this issue that in rat and human nephrosis, tyrosine phosphorylation of nephrin is reduced, and this is accompanied by a decrease in F-actin in glomeruli. This, together with previous studies, suggests that the nephrin protein complex is a signaling nexus that regulates actin dynamics in podocytes.

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