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Review
. 1991:35:35-40.

Interleukin 1 signal transduction

J Saklatvala  1 , F Guesdon
Affiliations
  • PMID: 1838232
Review

Interleukin 1 signal transduction

J Saklatvala et al. Agents Actions Suppl. 1991.

Abstract

Interleukin 1 signals through an 80kDa receptor to change protein kinase activity in fibroblasts. Two increases in protein phosphorylation have been identified: the EGF receptor and the small heat shock protein (hsp 27). Both involve serine and are similarly transient (maximal 5-15 minutes). The kinase activity differs from PKA or C. Hsp 27 can be used for its assay in extracts of stimulated cells.

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