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Review
. 2008 Apr;118(4):1311-21.
doi: 10.1172/JCI34261.

Helminth infections: the great neglected tropical diseases

Peter J Hotez  1 , Paul J Brindley, Jeffrey M Bethony, Charles H King, Edward J Pearce, Julie Jacobson
Affiliations
Review

Helminth infections: the great neglected tropical diseases

Peter J Hotez et al. J Clin Invest. 2008 Apr.

Abstract

Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.

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References

    1. Faust, E.C., Russell, P.F., and Jung, R.C. 1970.Craig and Faust’s clinical parasitology . 8th edition. Philadelphia, Lea & Febiger. p. 251.
    1. Cox F.E.G. History of human parasitology. Clin. Microbiol. Rev. 2002;15:595–612. - PMC - PubMed
    1. Hotez P.J., Ottesen E., Fenwick A., Molyneux D. The neglected tropical diseases: the ancient afflictions of stigma and poverty and the prospects for their control and elimination. Adv. Exp. Med. Biol. 2006;582:23–33. - PubMed
    1. Hotez P.J. Forgotten people and forgotten diseases, the neglected tropical diseases and their impact on global health and development. ASM Press. 2008 In press.
    1. Hotez P.J. China’s hookworms [abstract]. China Q. 2002;172:1029–1041.

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