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. 2008 Jun 2;3(6):1046-9.
doi: 10.1002/asia.200700391.

A heterogeneous-catalyst-based, microwave-assisted protocol for the synthesis of 2,2'-bipyridines

Lucas R Moore  1 , David A Vicic
Affiliations

A heterogeneous-catalyst-based, microwave-assisted protocol for the synthesis of 2,2'-bipyridines

Lucas R Moore et al. Chem Asian J. .

Abstract

A new method of preparing 2,2'-bipyridines with short reaction times by using microwave assistance and heterogeneous catalysts has been developed. With a Negishi-like protocol, it was found that Ni/Al(2)O(3)-SiO(2) afforded 2,2'-bipyridine products in up to 86% yield in 1 h. Palladium supported on alumina also provided yields of 2,2'-bipyridines comparable to those seen for homogeneous PEPPSI (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II)dichloride) and tetrakis(triphenylphosphanyl)palladium complexes.

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Figures

Scheme 1
Scheme 1
Scope of cross-couplings of 2-halo-pyridines withy pyridyl nucleophiles is highly dependent on substitution patterns.
See this image and copyright information in PMC

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