doi: 10.1126/stke.113pe14.
Silent assassin: oncogenic ras directs epigenetic inactivation of target genes
Affiliations
- PMID: 18385037
- DOI: 10.1126/stke.113pe14
Item in Clipboard
Silent assassin: oncogenic ras directs epigenetic inactivation of target genes
Sci Signal.
.
Abstract
Oncogenic transformation is associated with genetic changes and epigenetic alterations. A study now shows that oncogenic Ras uses a complex and elaborate epigenetic silencing program to specifically repress the expression of multiple unrelated cancer-suppressing genes through a common pathway. These results suggest that cancer-related epigenetic modifications may arise through a specific and instructive mechanism and that genetic changes and epigenetic alterations are intimately connected and contribute to tumorigenesis cooperatively.
Similar articles
-
RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.FASEB J. 2006 Mar;20(3):497-9. doi: 10.1096/fj.05-4586fje. Epub 2005 Dec 29. FASEB J. 2006. PMID: 16384911
-
An elaborate pathway required for Ras-mediated epigenetic silencing.Nature. 2007 Oct 25;449(7165):1073-7. doi: 10.1038/nature06251. Nature. 2007. PMID: 17960246 Free PMC article.
-
Gene methylation in gastric cancer.Clin Chim Acta. 2013 Sep 23;424:53-65. doi: 10.1016/j.cca.2013.05.002. Epub 2013 May 10. Clin Chim Acta. 2013. PMID: 23669186 Review.
-
Epigenetic drivers of genetic alterations.Adv Genet. 2010;70:309-23. doi: 10.1016/B978-0-12-380866-0.60011-3. Adv Genet. 2010. PMID: 20920753 Review.
-
Epigenetic changes in solid and hematopoietic tumors.Semin Oncol. 2005 Oct;32(5):521-30. doi: 10.1053/j.seminoncol.2005.07.003. Semin Oncol. 2005. PMID: 16210093 Review.
Cited by
-
Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth.Mol Cancer. 2011 May 24;10:63. doi: 10.1186/1476-4598-10-63. Mol Cancer. 2011. PMID: 21609483 Free PMC article.
-
Elucidating Ras protein as a dual therapeutic target for inflammation and cancer: a review.Discov Oncol. 2025 Jun 7;16(1):1029. doi: 10.1007/s12672-025-02783-x. Discov Oncol. 2025. PMID: 40483365 Free PMC article. Review.
-
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.Breast Cancer Res. 2009;11(6):R87. doi: 10.1186/bcr2457. Epub 2009 Dec 8. Breast Cancer Res. 2009. PMID: 19995452 Free PMC article.
-
Oncolytic Virotherapy: The Cancer Cell Side.Cancers (Basel). 2021 Feb 24;13(5):939. doi: 10.3390/cancers13050939. Cancers (Basel). 2021. PMID: 33668131 Free PMC article. Review.
-
Biophysical mechanism for ras-nanocluster formation and signaling in plasma membrane.PLoS One. 2009 Jul 9;4(7):e6148. doi: 10.1371/journal.pone.0006148. PLoS One. 2009. PMID: 19587789 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
