Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2008:2008:631414.
doi: 10.1155/2008/631414.

Comparison of C-reactive protein and serum amyloid a protein in septic shock patients

Domingos Dias Cicarelli  1 , Joaquim Edson Vieira, Fábio Ely Martins Benseñor
Affiliations
Comparative Study

Comparison of C-reactive protein and serum amyloid a protein in septic shock patients

Domingos Dias Cicarelli et al. Mediators Inflamm. 2008.

Abstract

Septic shock is a severe inflammatory state caused by an infectious agent. Our purpose was to investigate serum amyloid A (SAA) protein and C-reactive protein (CRP) as inflammatory markers of septic shock patients. Here we evaluate 29 patients in postoperative period, with septic shock, in a prospective study developed in a surgical intensive care unit. All eligible patients were monitored over a 7-day period by sequential organ failure assessment (SOFA) score, daily CRP, SAA, and lactate measurements. CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock.

PubMed Disclaimer

Figures

Figure 1
Figure 1
CRP evolution of survivors and nonsurvivors during the first week (NS). NS: not statistically significant.
Figure 2
Figure 2
SAA evolution of survivors and nonsurvivors during the first week (NS). NS: not statistically significant.
See this image and copyright information in PMC

References

    1. Luzzani A, Polati E, Dorizzi R, Rungatscher A, Pavan R, Merlini A. Comparison of procalcitonin and C-reactive protein as markers of sepsis. Critical Care Medicine. 2003;31(6):1737–1741. - PubMed
    1. Enguix A, Rey C, Concha A, Medina A, Coto D, Diéguez MA. Comparison of procalcitonin with C-reactive protein and serum amyloid for the early diagnosis of bacterial sepsis in critically ill neonates and children. Intensive Care Medicine. 2001;27(1):211–215. - PubMed
    1. Patel H, Fellowes R, Coade S, Woo P. Human serum amyloid A has cytokine-like properties. Scandinavian Journal of Immunology. 1998;48(4):410–418. - PubMed
    1. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. New England Journal of Medicine. 1999;340(6):448–454. - PubMed
    1. Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states. Current Opinion in Hematology. 2000;7(1):64–69. - PubMed

Publication types