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. 2008 Jun;29(6):1067-70.
doi: 10.3174/ajnr.A1046. Epub 2008 Apr 3.

Interval change in size of venous pouch canine bifurcation aneurysms over a 10-month period

T Tsumoto  1 , J K Song, Y Niimi, A Berenstein
Affiliations

Interval change in size of venous pouch canine bifurcation aneurysms over a 10-month period

T Tsumoto et al. AJNR Am J Neuroradiol. 2008 Jun.

Abstract

Background and purpose: The natural history study of experimental aneurysms is important for the evaluation of new endovascular occlusion devices. Our purpose was to evaluate the natural history of experimental venous pouch bifurcation aneurysms in mongrel dogs up to a 10-month period.

Materials and methods: Serial digital subtraction angiography was performed in 5 bifurcation aneurysms 1, 4, 7, and 10 months after surgical creation. Aneurysm dimensions, including height, width, and neck diameter, and animal body weights were measured. Comparisons of each parameter were performed using the Friedman test and the paired Wilcoxon signed-rank test.

Results: Four of 5 aneurysms were patent during a 10-month follow-up period. One aneurysm was regarded as a partially thrombosed aneurysm at 1 month, though the extent of partial thrombosis lessened at 10 months. Bifurcation aneurysms progressively increased in size (aneurysm height, width, and neck diameter) during the first several months.

Conclusion: If this experimental model is used to evaluate new endovascular devices for cerebral aneurysm treatment, investigators should be aware of early progressive aneurysm enlargement.

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Figures

Fig 1.
Fig 1.
Representative DSA 1 (A), 4 (B), 7 (C), and 10 (D) months after creation. The venous pouch bifurcation aneurysms progressively increase in size during the first several months before appearing to stabilize.
Fig 2.
Fig 2.
Representative DSA 1 (A), 4 (B), 7 (C), and 10 (D) months after creation. The extent of partial thrombosis is less at 10 months than at the time of aneurysm creation.
Fig 3.
Fig 3.
Bar graphs illustrate mean sizes of height (A), width (B), neck diameter (C), and body weight (D) in each group.
See this image and copyright information in PMC

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