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. 2007 Jul;41(1):50-7.
doi: 10.3164/jcbn.2007007.

Serum cardiac markers in patients with acute myocardial infarction: oxidative stress, C-reactive protein and N-terminal probrain natriuretic Peptide

Seçil Kasap  1 , Aymelek Gönenç, Derya Erten Sener, Ismet Hisar
Affiliations

Serum cardiac markers in patients with acute myocardial infarction: oxidative stress, C-reactive protein and N-terminal probrain natriuretic Peptide

Seçil Kasap et al. J Clin Biochem Nutr. 2007 Jul.

Abstract

The aim of this study was to investigate the predictive value of an oxidative stress, C-reactive protein (CRP) and N-terminal probrain natriuretic peptide (NT-proBNP) biomarkers in acute myocardial infarction (AMI). The study population contained 100 patients with AMI and 40 healthy subjects. Malondialdehyde (MDA) was measured as thiobarbituric acid reactive substances. Total antioxidant status (TAC) was assayed with colorimetric method. CRP and NT-proBNP was quantitated by immunoassay. MDA, CRP and NT-proBNP levels were found significantly high in patients with AMI as compared to healthy controls (p<0.01). Patients were divided into six groups based on the presence of disease history before AMI. In patients with non-disease before AMI. MDA, CRP and NT-proBNP levels were lowest among the patient groups. MDA levels in patients with hyperlipidemia/ diabetes/renal disease were higher than the other groups. TAC levels in patients with hypertension were lower than as compared to healthy controls (p<0.05). CRP levels in hypertension + hyperlipidemia patients and NT-proBNP levels in cardiovascular + hypertension patients were found high as compared to other patient groups. It is concluded that serum levels of MDA, CRP and NT-proBNP were significantly increased in patients with AMI and these markers were strongly predictive in AMI.

Keywords: C-reactive protein; N-terminal probrain natriuretic peptide; acute myocardial infarction; oxidative stress.

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References

    1. Farmer J.A., Gotto A.M., Jr. Dyslipidemia and other risk factors for coronary artery disease in Heart Disease: A Textbook of Cardiovascular Medicine. In: Braunwald E., Saunders W.B., editors. 5th Ed. Philadelphia: 1997. pp. 1126–1160.
    1. Loeper J., Goy J., Rozenstajin L. Lipid peroxidation and protective enzymes during myocardial infarction. Clin. Chim. Acta. 1991;196:119–126. - PubMed
    1. Espat N.J., Helton W.S. Oxygen free radicals, oxidative stress, and antioxidants in critical illness. Support Line. 2000;22:11–20.
    1. Zweier J.L., Flahertly J.T., Weisfeldt M.L. Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc. Natl. Acad. Sci. USA. 1987;84:1404–1407. - PMC - PubMed
    1. Slater T. Free-radical mechanism in tissue injury. Biochem. J. 1984;222:1–15. - PMC - PubMed