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. 2007 Nov;16(4):167-72.

Challenges associated with controlled psychopharmacological research trials in adolescents with eating disorders

Mark L Norris  1 , Wendy Spettigue, Annick Buchholz, Katherine A Henderson
Affiliations

Challenges associated with controlled psychopharmacological research trials in adolescents with eating disorders

Mark L Norris et al. J Can Acad Child Adolesc Psychiatry. 2007 Nov.

Abstract
in English, French

Introduction: Eating disordered populations present many unique challenges both to clinicians and researchers. Adolescents with eating disorders can be difficult to treat, and the challenges associated with research in this area can be significant.

Objectives: This paper was written with three main objectives in mind: to comment on some of the barriers impeding mental health research in general, to highlight challenges faced in the design and implementation of ED-specific studies, and to integrate personal insight into some of the many challenges that we have encountered during our experience with a randomized clinical trial examining the efficacy of olanzapine for the adjunctive treatment of youth with Anorexia Nervosa.

Discussion: It is hoped that providing information in this context will allow researchers greater insight into some of the many challenges that accompany study of this cohort.

Introduction: Les adolescents souffrant de troubles du comportement alimentaire présentent des défis uniques aux cliniciens et aux chercheurs. Ces adolescents sont difficiles à traiter et la recherche dans ce domaine s’accompagne de défis significatifs.

Ojectifs: Les objectifs visés par cet article sont triples: expliquer les obstacles auxquels se heurte généralement la recherche en santé mentale; faire ressortir les défis que posent la conception et l’application des études qui portent spécifiquement sur les troubles du comportement alimentaire; intégrer l’expérience personnelle dans la résolution des problèmes auxquels nous avons été confrontés lors d’un essai clinique aléatoire sur l’efficacité de l’olanzapine dans le traitement complémentaire d’adolescents anoerxiques.

Discussion: Nous espérons que ces résultats aideront les chercheurs à mieux comprendre les nombreux défis posés par l’étude de cette population.

Keywords: adolescents; challenges; eating disorders; obstacles; research.

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