This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 2008 May 8;51(9):2600-5.

doi: 10.1021/jm070421s. Epub 2008 Apr 5.

Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors

Kyung Bo Kim¹, Craig M Crews

Affiliations

PMID: 18393403
PMCID: PMC2556560
DOI: 10.1021/jm070421s

Review

Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors

Kyung Bo Kim et al. J Med Chem. 2008.

. 2008 May 8;51(9):2600-5.

doi: 10.1021/jm070421s. Epub 2008 Apr 5.

Authors

Kyung Bo Kim¹, Craig M Crews

Affiliation

¹ Department of Pharmaceutical Sciences, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536-0082, USA. kbkim2@uky.edu

PMID: 18393403
PMCID: PMC2556560
DOI: 10.1021/jm070421s

No abstract available

PubMed Disclaimer

Figures

Chart 1 — Chart 1
(A) Synthetic and (B) Natural Product Proteasome Inhibitors

Chart 2 — Chart 2
(A) Terpenoids and (B) Dietary Flavonoids Having Proteasome Inhibitory Activities

See this image and copyright information in PMC

Similar articles

Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.
Yang H, Landis-Piwowar KR, Chen D, Milacic V, Dou QP. Yang H, et al. Curr Protein Pept Sci. 2008 Jun;9(3):227-39. doi: 10.2174/138920308784533998. Curr Protein Pept Sci. 2008. PMID: 18537678 Free PMC article. Review.
Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells.
Chen D, Chen MS, Cui QC, Yang H, Dou QP. Chen D, et al. Front Biosci. 2007 Jan 1;12:1935-45. doi: 10.2741/2199. Front Biosci. 2007. PMID: 17127432
Clogging the Ubiquitin-Proteasome Machinery with Marine Natural Products: Last Decade Update.
Della Sala G, Agriesti F, Mazzoccoli C, Tataranni T, Costantino V, Piccoli C. Della Sala G, et al. Mar Drugs. 2018 Nov 26;16(12):467. doi: 10.3390/md16120467. Mar Drugs. 2018. PMID: 30486251 Free PMC article. Review.
Natural Compounds as Protease Inhibitors in Therapeutic Focus on Cancer Therapy.
Kakali B. Kakali B. Anticancer Agents Med Chem. 2024;24(16):1167-1181. doi: 10.2174/0118715206303964240708095110. Anticancer Agents Med Chem. 2024. PMID: 38988167 Review.
Targeting the proteasome pathway.
Tsukamoto S, Yokosawa H. Tsukamoto S, et al. Expert Opin Ther Targets. 2009 May;13(5):605-21. doi: 10.1517/14728220902866851. Expert Opin Ther Targets. 2009. PMID: 19397479 Review.

See all similar articles

Cited by

Neurotrophic natural products: chemistry and biology.
Xu J, Lacoske MH, Theodorakis EA. Xu J, et al. Angew Chem Int Ed Engl. 2014 Jan 20;53(4):956-87. doi: 10.1002/anie.201302268. Epub 2013 Dec 18. Angew Chem Int Ed Engl. 2014. PMID: 24353244 Free PMC article. Review.
Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system.
Buckley DL, Crews CM. Buckley DL, et al. Angew Chem Int Ed Engl. 2014 Feb 24;53(9):2312-30. doi: 10.1002/anie.201307761. Epub 2014 Jan 23. Angew Chem Int Ed Engl. 2014. PMID: 24459094 Free PMC article. Review.
Proteasome regulators: activators and inhibitors.
Huang L, Chen CH. Huang L, et al. Curr Med Chem. 2009;16(8):931-9. doi: 10.2174/092986709787581860. Curr Med Chem. 2009. PMID: 19275603 Free PMC article. Review.
Proteomics guided discovery of flavopeptins: anti-proliferative aldehydes synthesized by a reductase domain-containing non-ribosomal peptide synthetase.
Chen Y, McClure RA, Zheng Y, Thomson RJ, Kelleher NL. Chen Y, et al. J Am Chem Soc. 2013 Jul 17;135(28):10449-56. doi: 10.1021/ja4031193. Epub 2013 Jul 2. J Am Chem Soc. 2013. PMID: 23763305 Free PMC article.
Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.
Gulder TA, Moore BS. Gulder TA, et al. Angew Chem Int Ed Engl. 2010 Dec 3;49(49):9346-67. doi: 10.1002/anie.201000728. Angew Chem Int Ed Engl. 2010. PMID: 20927786 Free PMC article. Review.

See all "Cited by" articles

References

1. Henry CM. High hopes for RNA interference. Chem. Eng. News. 2003;81:32–36.
2. Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 2003;21:635–637. - PubMed
1. Schreiber SL. Chemical genetics resulting from a passion for synthetic organic chemistry. Bioorg. Med. Chem. 1998;6:1127–1152. - PubMed
1. Adams J. Development of the proteasome inhibitor PS-341. Oncologist. 2002;7:9–16. - PubMed
1. Ciechanover A, Orian A, Schwartz AL. Ubiquitin-mediated proteolysis: biological regulation via destruction. BioEssays. 2000;22:442–451. - PubMed
1. Myung J, Kim KB, Crews CM. The ubiquitin–proteasome pathway and proteasome inhibitors. Med. Res. Rev. 2001;21:245–273. - PMC - PubMed
2. Kim KB, Crews CM. Natural Product and Synthetic Proteasome Inhibitors. In: Adams J, editor. Cancer Drug Discovery and Development: Proteasome Inhibitors in Cancer Therapy. Totowa, NJ: Humana Press Inc.; pp. 47–63.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources