Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 May 8;51(9):2600-5.
doi: 10.1021/jm070421s. Epub 2008 Apr 5.

Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors

Kyung Bo Kim  1 , Craig M Crews
Affiliations
Review

Chemical genetics: exploring the role of the proteasome in cell biology using natural products and other small molecule proteasome inhibitors

Kyung Bo Kim et al. J Med Chem. .
No abstract available

PubMed Disclaimer

Figures

Chart 1
Chart 1
(A) Synthetic and (B) Natural Product Proteasome Inhibitors
Chart 2
Chart 2
(A) Terpenoids and (B) Dietary Flavonoids Having Proteasome Inhibitory Activities
See this image and copyright information in PMC

References

    1. Henry CM. High hopes for RNA interference. Chem. Eng. News. 2003;81:32–36.
    2. Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 2003;21:635–637. - PubMed
    1. Schreiber SL. Chemical genetics resulting from a passion for synthetic organic chemistry. Bioorg. Med. Chem. 1998;6:1127–1152. - PubMed
    1. Adams J. Development of the proteasome inhibitor PS-341. Oncologist. 2002;7:9–16. - PubMed
    1. Ciechanover A, Orian A, Schwartz AL. Ubiquitin-mediated proteolysis: biological regulation via destruction. BioEssays. 2000;22:442–451. - PubMed
    1. Myung J, Kim KB, Crews CM. The ubiquitin–proteasome pathway and proteasome inhibitors. Med. Res. Rev. 2001;21:245–273. - PMC - PubMed
    2. Kim KB, Crews CM. Natural Product and Synthetic Proteasome Inhibitors. In: Adams J, editor. Cancer Drug Discovery and Development: Proteasome Inhibitors in Cancer Therapy. Totowa, NJ: Humana Press Inc.; pp. 47–63.

Publication types

MeSH terms