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Review
. 2008;10(2):205.
doi: 10.1186/ar2384. Epub 2008 Mar 31.

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets

Annette H M van der Helm-van Mil  1 , Tom W J Huizinga
Affiliations
Review

Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets

Annette H M van der Helm-van Mil et al. Arthritis Res Ther. 2008.

Abstract

In the past few years considerable advances have been made in the genetics of susceptibility to rheumatoid arthritis (RA). For decades the HLA-DRB1 alleles were the only extensively replicated genetic factor, but more genetic risk factors have now been identified that predispose to RA. Interestingly, several of the observed genetic variants conferred risk to anticitrulline-peptide antibody (ACPA)-positive RA and two variants may be restricted to ACPA-negative RA, pointing to the need for subclassification of RA. The current manuscript reviews recently identified genetic factors predisposing to ACPA-positive RA and ACPA-negative RA. Additionally, although being scarcely explored, genetic variants affecting the severity of disease course are discussed.

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References

    1. Harrison BJ, Symmons DP, Barrett EM, Silman AJ. The performance of the 1987 ARA classification criteria for rheumatoid arthritis in a population based cohort of patients with early inflammatory polyarthritis. American Rheumatism Association. J Rheumatol. 1998;25:2324–2330. - PubMed
    1. Harrison B, Symmons D. Early inflammatory polyarthritis: results from the Norfolk Arthritis Register with a review of the literature. II. Outcome at three years. Rheumatology (Oxford) 2000;39:939–949. doi: 10.1093/rheumatology/39.9.939. - DOI - PubMed
    1. Symmons DP, Hazes JM, Silman AJ. Cases of early inflammatory polyarthritis should not be classified as having rheumatoid arthritis. J Rheumatol. 2003;30:902–904. - PubMed
    1. Green M, Marzo-Ortega H, McGonagle D, Wakefield R, Proud-man S, Conaghan P, Gooi J, Emery P. Persistence of mild, early inflammatory arthritis: the importance of disease duration, rheumatoid factor, and the shared epitope. Arthritis Rheum. 1999;42:2184–2188. doi: 10.1002/1529-0131(199910)42:10<2184::AID-ANR20>3.0.CO;2-2. - DOI - PubMed
    1. Machold KP, Stamm TA, Eberl GJ, Nell VK, Dunky A, Uffmann M, Smolen JS. Very recent onset arthritis – clinical, laboratory, and radiological findings during the first year of disease. J Rheumatol. 2002;29:2278–2287. - PubMed