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Review
. 2008:169:97-115.
doi: 10.1016/S0079-6123(07)00006-4.

Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

Ted Abel  1 , Peter V Nguyen
Affiliations
Review

Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

Ted Abel et al. Prog Brain Res. 2008.

Abstract

The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.

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Figures

Fig. 1
Fig. 1
The cAMP/PKA signaling pathway critically regulates molecular components underlying long-term potentiation and long-term memory. In the postsynaptic neuron, PKA targets include NMDA and AMPA receptors, inhibitor-1 (I-1) and CREB. In the presynaptic terminal, PKA targets include RIM1α and synapsin. (See Color Plate 6.1 in color plate section.)
See this image and copyright information in PMC

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