Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

doi:10.1016/S0079-6123(07)00006-4

Review

. 2008:169:97-115.

doi: 10.1016/S0079-6123(07)00006-4.

Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

Ted Abel¹, Peter V Nguyen

Affiliations

PMID: 18394470
PMCID: PMC2914307
DOI: 10.1016/S0079-6123(07)00006-4

Review

Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

Ted Abel et al. Prog Brain Res. 2008.

. 2008:169:97-115.

doi: 10.1016/S0079-6123(07)00006-4.

Authors

Ted Abel¹, Peter V Nguyen

Affiliation

¹ University of Pennsylvania, Department of Biology, Biological Basis of Behavior Program, Philadelphia, PA 19104, USA.

PMID: 18394470
PMCID: PMC2914307
DOI: 10.1016/S0079-6123(07)00006-4

Abstract

The hippocampus is crucial for the consolidation of new declarative long-term memories. Genetic and behavioral experimentation have revealed that several protein kinases are critical for the formation of hippocampus-dependent long-term memories. Cyclic-AMP dependent protein kinase (PKA) is a serine-threonine kinase that has been strongly implicated in the expression of specific forms of hippocampus-dependent memory. We review evidence that PKA is required for hippocampus-dependent memory in mammals, and we highlight some of the proteins that have been implicated as targets of PKA. Future directions and open questions regarding the role of PKA in memory storage are also described.

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Figures

**Fig. 1**
The cAMP/PKA signaling pathway critically regulates molecular components underlying long-term potentiation and long-term memory. In the postsynaptic neuron, PKA targets include NMDA and AMPA receptors, inhibitor-1 (I-1) and CREB. In the presynaptic terminal, PKA targets include RIM1α and synapsin. (See Color Plate 6.1 in color plate section.)

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References

1. Abel T, Nguyen PV, Barad M, Deuel TAS, Kandel ER, Bourtchuladze R. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell. 1997;88:615–626. - PubMed
1. Abraham WC, Logan B, Greenwood JM, Dragunow M. Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus. J Neurosci. 2002;22:9626–9634. - PMC - PubMed
1. Ahi J, Radulovic J, Spiess J. The role of hippocampal signaling cascades in consolidation of fear memory. Behav Brain Res. 2004;149:17–31. - PubMed
1. Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER, Barco A. Chromatin acetylation, memory, and LTP are impaired in CBP(+/−) Mice: a model for the cognitive deficit in Rubinstein–Taybi syndrome and its amelioration. Neuron. 2004;42:947–959. - PubMed
1. Allen PB, Hvalby O, Jensen V, Errington ML, Ramsay M, Chaudry FA, Bliss TVP, Storm-Mathisen J, Morris RGM, Andersen P, Greengard P. Protein phosphatase-1 regulation in the induction of LTP: heterogeneous molecular mechanisms. J Neurosci. 2000;20:3537–3543. - PMC - PubMed

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[1] Abel T, Nguyen PV, Barad M, Deuel TAS, Kandel ER, Bourtchuladze R. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell. 1997;88:615–626. - PubMed

[2] Abel T, Nguyen PV, Barad M, Deuel TAS, Kandel ER, Bourtchuladze R. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell. 1997;88:615–626. - PubMed

[3] Abraham WC, Logan B, Greenwood JM, Dragunow M. Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus. J Neurosci. 2002;22:9626–9634. - PMC - PubMed

[4] Abraham WC, Logan B, Greenwood JM, Dragunow M. Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus. J Neurosci. 2002;22:9626–9634. - PMC - PubMed

[5] Ahi J, Radulovic J, Spiess J. The role of hippocampal signaling cascades in consolidation of fear memory. Behav Brain Res. 2004;149:17–31. - PubMed

[6] Ahi J, Radulovic J, Spiess J. The role of hippocampal signaling cascades in consolidation of fear memory. Behav Brain Res. 2004;149:17–31. - PubMed

[7] Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER, Barco A. Chromatin acetylation, memory, and LTP are impaired in CBP(+/−) Mice: a model for the cognitive deficit in Rubinstein–Taybi syndrome and its amelioration. Neuron. 2004;42:947–959. - PubMed

[8] Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER, Barco A. Chromatin acetylation, memory, and LTP are impaired in CBP(+/−) Mice: a model for the cognitive deficit in Rubinstein–Taybi syndrome and its amelioration. Neuron. 2004;42:947–959. - PubMed

[9] Allen PB, Hvalby O, Jensen V, Errington ML, Ramsay M, Chaudry FA, Bliss TVP, Storm-Mathisen J, Morris RGM, Andersen P, Greengard P. Protein phosphatase-1 regulation in the induction of LTP: heterogeneous molecular mechanisms. J Neurosci. 2000;20:3537–3543. - PMC - PubMed

[10] Allen PB, Hvalby O, Jensen V, Errington ML, Ramsay M, Chaudry FA, Bliss TVP, Storm-Mathisen J, Morris RGM, Andersen P, Greengard P. Protein phosphatase-1 regulation in the induction of LTP: heterogeneous molecular mechanisms. J Neurosci. 2000;20:3537–3543. - PMC - PubMed

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Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

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Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase

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