Comment
doi: 10.1016/j.cell.2008.03.017.
A tRNA with oncogenic capacity
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- PMID: 18394985
- DOI: 10.1016/j.cell.2008.03.017
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Comment
A tRNA with oncogenic capacity
Cell.
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Abstract
Overexpression of Brf1, a transcription factor of the RNA polymerase III apparatus, can transform cells in vitro and cause tumor formation in vivo. Marshall et al. (2008) now show that one of the transcriptional products of RNA polymerase III, the initiator tRNA(Met), mediates this effect, revealing an unexpected role for this tRNA in tumorigenesis.
Comment on
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Elevated tRNA(iMet) synthesis can drive cell proliferation and oncogenic transformation.Cell. 2008 Apr 4;133(1):78-89. doi: 10.1016/j.cell.2008.02.035. Cell. 2008. Retraction in: Cell. 2012 Oct 12;151(2):455. doi: 10.1016/j.cell.2012.09.009. PMID: 18394991 Retracted.