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. 2008 Apr 7;14(13):2044-8.
doi: 10.3748/wjg.14.2044.

Serum type IV collagen level is predictive for esophageal varices in patients with severe alcoholic disease

Satoshi Mamori  1 , Yasuyuki Searashi, Masato Matsushima, Kenichi Hashimoto, Shinichiro Uetake, Hiroshi Matsudaira, Shuji Ito, Hisato Nakajima, Hisao Tajiri
Affiliations

Serum type IV collagen level is predictive for esophageal varices in patients with severe alcoholic disease

Satoshi Mamori et al. World J Gastroenterol. .

Abstract

Aim: To determine factors predictive for esophageal varices in severe alcoholic disease (SAD).

Methods: Abdominal ultrasonography (US) was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal (UGI) endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables.

Results: Twenty-five patients (56.8%) had esophageal varices. A univariate analysis revealed a significant difference in age and type IV collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type IV collagen as the only independent variable predictive for esophageal varices (P = 0.017). The area under the curve (AUC) for type IV collagen as determined by the receiver operating characteristic (ROC) for predicting esophageal varices was 0.78.

Conclusion: This study suggests that the level of type IV collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD.

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Figures

Figure 1
Figure 1
Flow chart of patients in this study. EV: Esophageal varice.
Figure 2
Figure 2
Two independent factors correlated with the appearance of esophageal varices. Collagen: Collagen type IV (ng/mL); (+): Positive patients; (-): Negative patients.
Figure 3
Figure 3
The positive predictive value for esophageal varices of collagen type IV. Y-axis: Positive percentages of esophageal varices; X-axis: The total predictive value of esophageal varices; > 300 (600, 900): The positive predictive value of esophageal varices with a collagen type IV value > 300 (600, 900) ng/mL.
Figure 4
Figure 4
Receiver operating characteristics (ROC) curve of collagen type IV for the diagnosis of esophageal varices [area under curve = 0.7802, se (area) = 0.0704].
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