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. 2008 Apr;7(4):283-5.
doi: 10.1016/j.cmet.2008.03.013.

Bruton and Tec: new links in osteoimmunology

Brendan F Boyce  1 , Lianping Xing
Affiliations
Free article

Bruton and Tec: new links in osteoimmunology

Brendan F Boyce et al. Cell Metab. 2008 Apr.
Free article

Abstract

Enhanced and deficient immune responses are associated with abnormal bone homeostasis. A new study by Shinohara et al. (2008) shows that protein phosphorylation by the tyrosine kinases Bruton and Tec links immunity and bone as well as two signaling pathways in precursors of osteoclasts, the cells that degrade bone.

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