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. 2008 Apr 30;582(10):1537-41.
doi: 10.1016/j.febslet.2008.03.050. Epub 2008 Apr 7.

Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP

Yoan Chérasse  1 , Cédric Chaveroux, Céline Jousse, Anne-Catherine Maurin, Valérie Carraro, Laurent Parry, Pierre Fafournoux, Alain Bruhat
Affiliations
Free article

Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP

Yoan Chérasse et al. FEBS Lett. .
Free article

Abstract

The transcriptional activation of CHOP (C/EBP-homologous protein) by amino acid deprivation involves ATF2 and ATF4 binding at the amino acid response element within the promoter. In this report, we investigate the role of JDP2 (Jun Dimerization Protein 2) in the amino acid control of CHOP transcription following amino acid starvation. Our results show that JDP2 binds to the CHOP AARE in unstimulated cells and that its binding decreases following amino acid starvation. We demonstrate that JDP2 acts as a repressor and suggest that it could be functionally associated with HDAC3 to inhibit CHOP transcription.

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