Hematopoietic stem cells in transit--where's the niche?
- PMID: 18397748
- DOI: 10.1016/j.stem.2008.03.017
Hematopoietic stem cells in transit--where's the niche?
Abstract
In this issue of Cell Stem Cell, Min et al. (2008) identify Egr1 as a novel hematopoietic stem cell (HSC) transcription factor that regulates proliferation and mobilization of these cells. An improved understanding of Egr1 targets may lead to better strategies to expand populations of HSCs ex vivo for therapeutic applications.
Comment on
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The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.Cell Stem Cell. 2008 Apr 10;2(4):380-91. doi: 10.1016/j.stem.2008.01.015. Cell Stem Cell. 2008. PMID: 18397757
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