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. 1976 Sep 15;32(9):1178-9.
doi: 10.1007/BF01927612.

3-Hydroxy-3-methylglutaric acid and triton-induced hyperlipidemia in rats

S Y Yousufzai, M Siddiqi

3-Hydroxy-3-methylglutaric acid and triton-induced hyperlipidemia in rats

S Y Yousufzai et al. Experientia. .

Abstract

3-Hydroxy-3-methylglutaric acid (HMG) significantly decreased cholesterol, triglyceride and phospholipid levels in whole serum, serum beta-lipoproteins and liver of Triton-induced hyperlipidemic rats. Therapeutically 50 mg HMG/kg is equivalent to 200 mg nicotinic acid/kg in lowering all these lipid parameters. HMG may exert its hypolipidemic effect through inhibition of lipoprotein synthesis.

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