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Comment
. 2008 Apr 15;105(15):5655-6.
doi: 10.1073/pnas.0802300105. Epub 2008 Apr 8.

Morphing peptide backbones into heterocycles

Christopher T Walsh  1 , Elizabeth M Nolan
Affiliations
Comment

Morphing peptide backbones into heterocycles

Christopher T Walsh et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Nonribosomal and ribosomal heterocyclic peptides. (A) Isopenicillin N, yersiniabactin, and vancomycin are products of NRPS machinery. Patellamides A and C are ribsomally derived peptides. (B) Conversion of a Gly-Ser-Cys tripeptide into a oxazole–thiazole pair via an oxazoline–thiazoline intermediate. This two-step process of cyclodehydration and aromatization occurs in microcin, patellamide, and now SLS posttranslational modification.
See this image and copyright information in PMC

Comment on

  • Discovery of a widely distributed toxin biosynthetic gene cluster.
    Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Lee SW, et al. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84. doi: 10.1073/pnas.0801338105. Epub 2008 Mar 28. Proc Natl Acad Sci U S A. 2008. PMID: 18375757 Free PMC article.

References

    1. Schofield CJ, et al. Proteins of the penicillin biosynthesis pathway. Curr Opin Chem Biol. 1997;7:857–864. - PubMed
    1. Hubbard BK, Walsh CT. Vancomycin assembly: Nature's way. Angew Chem Int Ed. 2003;42:730–765. - PubMed
    1. Lee SW, et al. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci USA. 2008;105:5879–5884. - PMC - PubMed
    1. Fischbach MA, Walsh CT. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms. Chem Rev. 2006;106:3468–3496. - PubMed
    1. Crosa JH, Walsh CT. Genetics and assembly line enzymology of siderophore biosynthesis in bacteria. Microb Mol Biol Rev. 2002;66:223–249. - PMC - PubMed

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