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Review
. 2008 Apr 10;58(1):3-5.
doi: 10.1016/j.neuron.2008.03.023.

Neurogenesis or neuronal specification: phosphorylation strikes again!

Helen C Lai  1 , Jane E Johnson
Affiliations
Free article
Review

Neurogenesis or neuronal specification: phosphorylation strikes again!

Helen C Lai et al. Neuron. .
Free article

Abstract

How basic helix-loop-helix (bHLH) transcription factors control neurogenesis and neuronal subtype specification through transcriptional mechanisms mediated by cell signaling remains to be fully elucidated. In this issue of Neuron, Ma et al. discover that phosphorylation via GSK3 of the bHLH factor, Ngn2 (Neurog2), adds a neuronal subtype-specific program to its functional repertoire that is activated in the developing neural tube in vivo.

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