Review
doi: 10.1073/pnas.0802298105.
Epub 2008 Apr 9.
Knockout punches with a fistful of zinc fingers
Affiliations
- PMID: 18401029
- PMCID: PMC2311346
- DOI: 10.1073/pnas.0802298105
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Review
Knockout punches with a fistful of zinc fingers
Proc Natl Acad Sci U S A.
.
No abstract available
Conflict of interest statement
The author declares no conflict of interest.
Figures
ZFN knockouts. In the absence of a template for HR, ZFN-induced DSBs are fixed by NHEJ, which generates imprecise junctions, including both deletions and additions at the joint.
Comment on
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Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5809-14. doi: 10.1073/pnas.0800940105. Epub 2008 Mar 21. Proc Natl Acad Sci U S A. 2008. PMID: 18359850 Free PMC article.
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References
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- Bibikova M, Beumer K, Trautman JK, Carroll D. Enhancing gene targeting with designed zinc finger nucleases. Science. 2003;300:764. - PubMed
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