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. 2007 Dec;25(4):469-78.

Adults' perceived prevalence of enteric fever predicts laboratory-validated incidence of typhoid fever in children

Xinguang Chen  1 , Bonita Stanton, Al Pach, Andrew Nyamete, R Leon Ochiai, Linda Kaljee, Baiqing Dong, Dipika Sur, S K Bhattacharya, Siti Sapardiyah Santoso, Magdarina Agtini, Zahid Memon, Zulfiqar Bhutta, Canh Gia Do, Lorenz von Seidlein, John Clemens
Affiliations

Adults' perceived prevalence of enteric fever predicts laboratory-validated incidence of typhoid fever in children

Xinguang Chen et al. J Health Popul Nutr. 2007 Dec.

Abstract

This study was undertaken to develop a model to predict the incidence of typhoid in children based on adults' perception of prevalence of enteric fever in the wider community. Typhoid cases among children, aged 5-15 years, from epidemic regions in five Asian countries were confirmed with a positive Salmonella Typhi culture of the blood sample. Estimates of the prevalence of enteric fever were obtained from random samples of adults in the same study sites. Regression models were used for establishing the prediction equation. The percentages of enteric fever reported by adults and cases of typhoid incidence per 100,000, detected through blood culture were 4.7 and 24.18 for Viet Nam, 3.8 and 29.20 for China, 26.3 and 180.33 for Indonesia, 66.0 and 454.15 for India, and 52.7 and 407.18 for Pakistan respectively. An established prediction equation was: incidence of typhoid (1/100,000= -2.6946 + 7.2296 x reported prevalence of enteric fever (%) (F=31.7, p<0.01; R2=0.992). Using adults' perception of prevalence of disease as the basis for estimating its incidence in children provides a cost-effective behavioural epidemiologic method to facilitate prevention and control of the disease.

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Figures

Fig. 1
Fig. 1
Geographic location of the five study sites in China, India, Indonesia, Pakistan, and Viet Nam
Fig. 2
Fig. 2
Perceived prevalence of enteric fever by adults appears to be associated with laboratory-confirmed incidence of Salmonella-associated typhoid in children
See this image and copyright information in PMC

References

    1. Bhan MK, Bahl R, Bhatnagar S. Typhoid and paratyphoid fever. Lancet. 2005;366:749–62. - PubMed
    1. Acharya IL, Lowe CU, Thapa R, Gurubacharya VL, Shrestha MB, Cadoz M, et al. Prevention of typhoid fever in Nepal with the Vi capsular polysaccharide of Salmonella Typhi. A preliminary report. N Engl J Med. 1987;317:1101–4. - PubMed
    1. Lin FY, Vo AH, Phan VB, Nguyen TT, Bryla D, Tran CT, et al. The epidemiology of typhoid fever in the Dong Thap province, Mekong Delta region of Vietnam. Am J Trop Med Hyg. 2000;62:644–8. - PubMed
    1. Simanjuntak CH, Paleologo FP, Punjabi NH, Darmowigoto R, Soeprawoto, Totosudirjo H, et al. Oral immunisation against typhoid fever in Indonesia with Ty21a vaccine. Lancet. 1991;338:1055–9. - PubMed
    1. Sinha A, Sazawal S, Kumar R, Sood S, Reddaiah VP, Singh B, et al. Typhoid fever in children aged less than 5 years. Lancet. 1999;354:734–7. - PubMed

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