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Editorial
. 2008 Apr 15;51(15):1438-9.
doi: 10.1016/j.jacc.2008.01.017.

An imperfect syllogism: granulocyte colony-stimulating factor mobilization and cardiac regeneration

Samuel C Dudley Jr, David Simpson
Editorial

An imperfect syllogism: granulocyte colony-stimulating factor mobilization and cardiac regeneration

Samuel C Dudley Jr et al. J Am Coll Cardiol. .

Abstract

Despite significant progress in pharmaceuticals and medical technology, heart failure remains a major worldwide problem. Most often, heart failure manifests when myocardium becomes injured, dies, and is replaced by fibrous scar tissue. Until recently, it was thought that the heart had no ability to regenerate injured cardiomyocytes, but in 2001, Orlic et al. (1,2) fundamentally altered our thinking by showing that mobilized or directly applied bone marrow (BM)–derived progenitor cells improved myocardial function after infarction. With this observation, the race was on to find the methods and cells that would provide the greatest benefit for cardiac regeneration (3).

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References

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    1. Orlic D, Kajstura J, Chimenti S, et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A. 2001;98:10344–9. - PMC - PubMed
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    1. Ott I, Keller U, Knoedler M, et al. Endothelial-like cells expanded from CD34+ blood cells improve left ventricular function after experimental myocardial infarction. FASEB J. 2005;19:992–4. - PubMed

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