Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Sep 10;34(1):35-43.
doi: 10.1007/BF00284432.

Localisation of the human ABO: Np-1: AK-1 linkage group by regional assignment of AK-1 to 9q34

M A Ferguson-Smith, D A Aitken, C Turleau, J de Grouchy

Localisation of the human ABO: Np-1: AK-1 linkage group by regional assignment of AK-1 to 9q34

M A Ferguson-Smith et al. Hum Genet. .

Abstract

Quantitative red cell adenylate kinase (AK-1) assay has been used in 8 patients with partial duplication or deletion of chromosome 9 in an attempt to find the precise intrachromosomal location of the structural gene locus. All regions of chromosome 9 are represented in abnormal dosage in at least one patient. A 43% increase in AK-1 activity was found to be associated with duplication of the terminal band of the long arm of chromosome 9. Duplication of all other parts of chromosome 9 were associated with normal enzyme activity. These findings not only confirm the assignment of the AK-1 locus to chromosome 9 made previously in somatic cell hybrids, but suggest a more precise assignment to region 9q33 leads to qter. This places the ABO:Np-1:AK-1 linkage group at the distal end of the long arm of chromosome 9.

PubMed Disclaimer

References

    1. Humangenetik. 1975 Sep 23;29(3):233-41 - PubMed
    1. Nat New Biol. 1973 Jun 27;243(130):271-4 - PubMed
    1. Lancet. 1963 Oct 5;2(7310):700-3 - PubMed
    1. Ann Hum Genet. 1968 Jan;31(3):237-42 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Nov;72(11):4526-30 - PubMed

LinkOut - more resources