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Review
. 2008 Apr 10;358(15):1590-602.
doi: 10.1056/NEJMra0706737.

The challenge of HIV-1 subtype diversity

Barbara S Taylor  1 , Magdalena E Sobieszczyk, Francine E McCutchan, Scott M Hammer
Affiliations
Review

The challenge of HIV-1 subtype diversity

Barbara S Taylor et al. N Engl J Med. .

Erratum in

  • N Engl J Med. 2008 Oct 30;359(18):1972
  • The challenge of HIV-1 subtype diversity.
    Taylor BS, Hammer SM. Taylor BS, et al. N Engl J Med. 2008 Oct 30;359(18):1965-6. doi: 10.1056/NEJMc086373. N Engl J Med. 2008. PMID: 18971501 No abstract available.
No abstract available

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Figures

Figure 1
Figure 1. Evolution of Diversity in HIV-1 during the Typical Viral Life Cycle and Creation of Unique Recombinant Forms in the Context of Coinfection with Two Subtypes
RT denotes reverse transcriptase.
Figure 2
Figure 2
Current Global Distribution of HIV-1 Subtypes and Recombinant Forms.
Figure 3
Figure 3. Predominant Amino Acid (AA) Changes Conferred by Polymorphisms in HIV-1 Protease, According to Subtype
AA sequences for HIV-1 protease were compared with a consensus subtype B sequence. Polymorphism data were obtained in May 2007 with the use of the HIVseq program from the Stanford HIV Drug Resistance Database (http://hivdb.stanford.edu/pages/algs/HIVseq.html). Polymorphisms in AAs 10 through 99 of the HIV-1 protease are shown for a given subtype if 10% or more of the sequences in the database were polymorphic at that site; the percentage of sequences that were polymorphic appear within the colored bars. The subtype is shown in the key, followed by the number of sequences in the analysis in parentheses. Black rectangles indicate the sites of major protease resistance mutations, and white rectangles indicate the sites of minor protease resistance mutations, according to the International AIDS Society–USA in 2007. The predominant AA changes at each site are shown on the left-hand side. Polymorphisms in HIV-1 reverse transcriptase AAs 40 through 240 are shown in the Supplementary Appendix, available with the full text of this article at www.nejm.org.
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