Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Apr;62(2):239-43.
doi: 10.1007/s11418-007-0221-0. Epub 2008 Jan 11.

Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon

Jyunichi Kawata  1 , Munekazu Kameda, Mitsuo Miyazawa
Affiliations

Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon

Jyunichi Kawata et al. J Nat Med. 2008 Apr.

Abstract

The composition of the volatile oil from Lithospermi Radix, the dried roots of Lithospermum erythrorhizon (Boraginaceae), has been investigated by capillary GC and GC-MS. To investigate the anti-inflammatory activity of the oil, in-vitro inhibition of ovine cyclooxygenase-1 and 2 (COX-1 and COX-2) activity by the oil was studied. Fifty-four components of the oil were identified, representing 92.74% of the oil. The main components were 2-methylbutanoic acid (21.50%), 3-methylbutanoic acid (12.61%), 2-methylpropanoic acid (8.99%), methyl linoleate (8.76%), methyl oleate (6.27%), methyl palmitate (6.06%), and 2-methyl-2-butenoic acid (5.74%). Highly selective COX-2 inhibition was observed; at 50 microg/ml the oil inhibited 38.8% of COX-2 activity.

PubMed Disclaimer

References

    1. Eur J Pharmacol. 1995 Jan 5;272(1):87-95 - PubMed
    1. Arch Biochem Biophys. 1995 Dec 1;324(1):26-34 - PubMed
    1. Int Immunopharmacol. 2001 Feb;1(2):229-36 - PubMed
    1. J Biomol Screen. 2001 Apr;6(2):101-10 - PubMed
    1. Life Sci. 2006 Jan 11;78(7):719-23 - PubMed

Publication types

LinkOut - more resources