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. 2007 Sep;3(4):317-31.
doi: 10.1007/s11302-007-9074-y. Epub 2007 Sep 12.

New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders

Paromita Majumder  1 , Cleber A Trujillo, Camila G Lopes, Rodrigo R Resende, Katia N Gomes, Katia K Yuahasi, Luiz R G Britto, Henning Ulrich
Affiliations

New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders

Paromita Majumder et al. Purinergic Signal. 2007 Sep.

Abstract

Ionotropic P2X and metabotropic P2Y purinergic receptors are expressed in the central nervous system and participate in the synaptic process particularly associated with acetylcholine, GABA, and glutamate neurotransmission. As a result of activation, the P2 receptors promote the elevation of free intracellular calcium concentration as the main signaling pathway. Purinergic signaling is present in early stages of embryogenesis and is involved in processes of cell proliferation, migration, and differentiation. The use of new techniques such as knockout animals, in vitro models of neuronal differentiation, antisense oligonucleotides to induce downregulation of purinergic receptor gene expression, and the development of selective inhibitors for purinergic receptor subtypes contribute to the comprehension of the role of purinergic signaling during neurogenesis. In this review, we shall discuss the participation of purinergic receptors in developmental processes and in brain physiology, including neuron-glia interactions and pathophysiology.

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Figures

Fig. 1
Fig. 1
Purine-induced signaling pathway involves the activation of P1 adenosine and P2 purinergic receptors and purine hydrolysis by ectonucleotidases. The scheme demonstrates purinergic receptor activity present in glia-glia, neuron-glia, and neuron-neuron interaction during neurogenesis as well as in the metabolism of the adult brain
See this image and copyright information in PMC

References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '1351659', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/1351659/'}]}
    2. Evans RJ, Derkach V, Surprenant A (1992) ATP mediates fast synaptic transmission in mammalian neurons. Nature 357:503–505 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PMC', 'value': 'PMC1907676', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC1907676/'}, {'type': 'PubMed', 'value': '1327385', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/1327385/'}]}
    2. Silinsky EM, Gerzanich V, Vanner SM (1992) ATP mediates excitatory synaptic transmission in mammalian neurones. Br J Pharmacol 106:762–763 - PMC - PubMed
    1. None
    2. Burnstock G (1978) A basis for distinguishing two types of purinergic receptor. In: Straub RW, Bolis L (eds) Cell membrane receptors for drugs and hormones: a multidisciplinary approach. Raven, New York, pp 107–118
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '2996968', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/2996968/'}]}
    2. Burnstock G, Kennedy C (1985) Is there a basis for distinguishing two types of P2 purinoceptor? Gen Pharmacol 16:433–440 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '10505627', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10505627/'}]}
    2. Brandle U, Zenner H-P, Ruppersberg JP (1999) Gene expression of P2X receptors in the developing inner ear of the rat. Neurosci Lett 273:105–108 - PubMed