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. 2005 Sep;1(3):219-27.
doi: 10.1007/s11302-005-6322-x. Epub 2005 Jul 29.

P2X(7) receptor: Death or life?

Elena Adinolfi  1 , Cinzia Pizzirani, Marco Idzko, Elisabeth Panther, Johannes Norgauer, Francesco Di Virgilio, Davide Ferrari
Affiliations

P2X(7) receptor: Death or life?

Elena Adinolfi et al. Purinergic Signal. 2005 Sep.

Abstract

The P2X(7) plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of P2X(7)-mediated responses, discussing recent information on this receptor. Particular attention has been paid to early and late signs of apoptosis and necrosis linked to activation of the receptor and to the emerging field of P2X(7) function in carcinogenesis.

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Figures

Figure 1
Figure 1
Low tonic or massive stimulation with ATP of P2X7-expressing cells causes a transient or a prolonged opening of the receptor-pore, respectively; this in-turn induces a modest or high intracellular Ca2+ concentration increase. Although changes in calcium are unlikely to be solely responsible for the duality in P2X7-mediated effects, they represent physiological triggering points in diverse upstream and downstream signalling processes, activating different cell functions and responses.
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