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Comparative Study
. 2008 Oct;20(5):986-99.
doi: 10.1017/S1041610208007254. Epub 2008 Apr 11.

Short-term practice effects in amnestic mild cognitive impairment: implications for diagnosis and treatment

Kevin Duff  1 , Leigh J Beglinger, Sara Van Der Heiden, David J Moser, Stephan Arndt, Susan K Schultz, Jane S Paulsen
Affiliations
Comparative Study

Short-term practice effects in amnestic mild cognitive impairment: implications for diagnosis and treatment

Kevin Duff et al. Int Psychogeriatr. 2008 Oct.

Abstract

Background: Practice effects have been widely reported in healthy older adults, but these improvements due to repeat exposure to test materials have been more equivocal in individuals with mild cognitive impairment (MCI).

Methods: The current study examined short-term practice effects in MCI by repeating a brief battery of cognitive tests across one week in 59 older adults with amnestic MCI and 62 intact older adults.

Results: Participants with amnestic MCI showed significantly greater improvements on two delayed recall measures (p < 0.01) compared to intact peers. All other practice effects were comparable between these two groups. Practice effects significantly improved scores in the MCI group so that 49% of them were reclassified as "intact" after one week, whereas the other 51% remained "stable" as MCI. Secondary analyses indicated the MCI-Intact group demonstrated larger practice effects on two memory measures than their peers (p < 0.01).

Conclusions: These results continue to inform us about the nature of memory deficits in MCI, and could have implications for the diagnosis and possible treatment of this amnestic condition.

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Conflict of interest statement

Conflict of interest: None.

References

    1. Barnett AG, van der Pols JC, Dobson AJ. Regression to the mean: what it is and how to deal with it. International Journal of Epidemiology. 2005;34:215–220. - PubMed
    1. Beglinger LJ, et al. Practice effects and the use of alternate forms in serial neuropsychological testing. Archives of Clinical Neuropsychology. 2005a;20:517–529. - PubMed
    1. Beglinger LJ, Tangphao-Daniels O, Kareken DA, Zhang L, Mohs R, Siemers ER. Neuropsychological test performance in healthy elderly volunteers before and after donepezil administration: a randomized, controlled study. Journal of Clinical Psychopharmacology. 2005b;25:159–165. - PubMed
    1. Belleville S, Gilbert B, Fontaine F, Gagnon L, Menard E, Gauthier S. Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: evidence from a cognitive intervention program. Dementia and Geriatric Cognitive Disorders. 2006;22:486–499. - PubMed
    1. Benedict RH, Zgaljardic DJ. Practice effects during repeated administrations of memory tests with and without alternate forms. Journal of Clinical and Experimental Neuropsychology. 1998;20:339–352. - PubMed

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