Cancer in acromegaly

Abstract

In recent years, it has become increasingly recognized that acromegaly predisposes to a variety of cancers, particularly colorectal and breast cancers, and perhaps haematological malignancies. However, these associations have been based mostly on small epidemiological surveys, and a propensity towards other malignancies might also become apparent in the future. This review assesses these three malignancies together with those of the thyroid and prostate, and discusses their pathogenesis, concentrating on the role of the growth hormone/insulin-like growth factor I (IGF-I) axis.