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Review
. 2008 May 15;473(2):183-7.
doi: 10.1016/j.abb.2008.03.028. Epub 2008 Mar 29.

Osteoblastic cells: differentiation and trans-differentiation

Moustapha Kassem  1 , Basem M Abdallah, Hamid Saeed
Affiliations
Review

Osteoblastic cells: differentiation and trans-differentiation

Moustapha Kassem et al. Arch Biochem Biophys. .

Abstract

The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation.

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