Review
doi: 10.1016/j.bbrc.2008.04.002.
Epub 2008 Apr 10.
MAP kinase: it's been longer than fifteen minutes
Affiliations
- PMID: 18406346
- DOI: 10.1016/j.bbrc.2008.04.002
Item in Clipboard
Review
MAP kinase: it's been longer than fifteen minutes
Biochem Biophys Res Commun.
.
Abstract
The review highlights evidence for different functions in the cell cycle of the two MAP kinase kinases, MEK1 and MEK2, and the two MAP kinases, ERK1 and ERK2. Functional differences may explain why instances of cell cycle arrest can be MEK1 or MEK2 dependent.
Similar articles
-
Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.Oncogene. 2007 Feb 8;26(6):813-21. doi: 10.1038/sj.onc.1209843. Epub 2006 Aug 7. Oncogene. 2007. PMID: 16909118
-
MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments.FASEB J. 2008 Feb;22(2):466-76. doi: 10.1096/fj.07-8650com. Epub 2007 Oct 10. FASEB J. 2008. PMID: 17928366
-
RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo.Int J Cancer. 2010 Mar 15;126(6):1367-77. doi: 10.1002/ijc.24950. Int J Cancer. 2010. PMID: 19816936
-
MEK1/2 dual-specificity protein kinases: structure and regulation.Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. doi: 10.1016/j.bbrc.2011.11.145. Epub 2011 Dec 8. Biochem Biophys Res Commun. 2012. PMID: 22177953 Review.
-
ERK1/2 MAP kinases in cell survival and apoptosis.IUBMB Life. 2006 Nov;58(11):621-31. doi: 10.1080/15216540600957438. IUBMB Life. 2006. PMID: 17085381 Review.
Cited by
-
ERK2 is essential for the growth of human epithelioid malignant mesotheliomas.Int J Cancer. 2011 Sep 1;129(5):1075-86. doi: 10.1002/ijc.25763. Epub 2011 Jan 6. Int J Cancer. 2011. PMID: 21710492 Free PMC article.
-
[α-Enolase (ENO1) inhibits epithelial-mesenchymal transition in the A549 cell line by suppressing ERK1/2 phosphorylation].Zhongguo Fei Ai Za Zhi. 2013 May;16(5):221-6. doi: 10.3779/j.issn.1009-3419.2013.05.01. Zhongguo Fei Ai Za Zhi. 2013. PMID: 23676977 Free PMC article. Chinese.
-
Tight junctions in the testis: new perspectives.Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1621-35. doi: 10.1098/rstb.2010.0010. Philos Trans R Soc Lond B Biol Sci. 2010. PMID: 20403874 Free PMC article. Review.
-
Pharmacological analyses of protein kinases regulating egg maturation in marine nemertean worms: a review and comparison with Mammalian eggs.Mar Drugs. 2010 Aug 24;8(8):2417-34. doi: 10.3390/md8082417. Mar Drugs. 2010. PMID: 20948915 Free PMC article. Review.
-
Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression.Mol Cell Proteomics. 2010 Jun;9(6):1167-81. doi: 10.1074/mcp.M900335-MCP200. Epub 2010 Jan 23. Mol Cell Proteomics. 2010. PMID: 20097925 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
