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. 1991 Feb 22;251(4996):936-9.
doi: 10.1126/science.1840698.

A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF

S Higashiyama  1 , J A Abraham, J Miller, J C Fiddes, M Klagsbrun
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A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF

S Higashiyama et al. Science. .

Abstract

Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smooth muscle cells than is EGF. HB-EGF is also expressed in cultured human macrophages and may be involved in macrophage-mediated cellular proliferation.

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