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Review
. 2008 Apr 17;3(4):201-2.
doi: 10.1016/j.chom.2008.03.005.

(C)Re-combining textbook models of virus spread within the host

Erik S Barton  1 , Douglas W White
Affiliations
Free article
Review

(C)Re-combining textbook models of virus spread within the host

Erik S Barton et al. Cell Host Microbe. .
Free article

Abstract

Classic viral pathogenesis models postulate that tissues supporting efficient virus replication promote virus dissemination, which culminates in clinical illness. In this issue of Cell Host & Microbe, Sacher and colleagues use Cre/loxP recombination to label murine cytomegalovirus during replication in distinct cell types in vivo. Strikingly, they demonstrate that the most productive cell type in the host-the hepatocyte-contributes no progeny to dissemination to other tissues.

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