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Review
. 2008 May;128(5):1064-7.
doi: 10.1038/jid.2008.85.

T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis

Andrew Blauvelt  1
Affiliations
Review

T-helper 17 cells in psoriatic plaques and additional genetic links between IL-23 and psoriasis

Andrew Blauvelt. J Invest Dermatol. 2008 May.

Abstract

T-helper 17 (Th17) cells are a newly appreciated T-cell subset, distinct from both Th1 and Th2 cells, that have been implicated in the pathogenesis of psoriasis and other autoimmune inflammatory diseases (Figure 1) (Fitch et al., 2007; Kastelein et al., 2007). IL-23 stimulates survival and proliferation of Th17 cells and thus serves as a key master cytokine regulator for these diseases.

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Figures

Figure 1
Figure 1
Th17 cells are distinct from Th1 cells, differentiate in the presence of IL-1 and IL-6, proliferate in response to IL-23, and secrete a characteristic set of cytokines. (Modified from Fitch et al., 2007.)
Figure 2
Figure 2
Schematic of the related heterodimers IL-23 and IL-12 and their related heterodimeric cytokine receptors, indicating (in red circles) the subunits where polymorphisms in genes encoding these proteins have been linked to development of psoriasis. (Modified from Blauvelt, 2007.)
See this image and copyright information in PMC

Comment on

References

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