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. 2008 Jun;52(6):2276-8.
doi: 10.1128/AAC.01584-07. Epub 2008 Apr 14.

In vitro susceptibility of isolates of Francisella tularensis types A and B from North America

Sandra K Urich  1 , Jeannine M Petersen
Affiliations

In vitro susceptibility of isolates of Francisella tularensis types A and B from North America

Sandra K Urich et al. Antimicrob Agents Chemother. 2008 Jun.

Abstract

Due to concern that Francisella tularensis, the causative agent of tularemia, may be used as a bioterrorist weapon, the Clinical and Laboratory Standards Institute recently provided a susceptibility testing method with breakpoints. Here, 169 isolates (92 type A and 77 type B) from North America were tested against seven antimicrobial agents (streptomycin, gentamicin, tetracycline, doxycycline, ciprofloxacin, levofloxacin, and chloramphenicol) used for the treatment of tularemia. The MICs for all of the isolates fell within the susceptible range. In addition, all isolates had MICs for erythromycin of 0.5 to 4 microg/ml, in contrast to an MIC of >256 microg/ml for the common laboratory strain LVS (live vaccine strain).

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