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. 1976 Aug-Sep;16(8-9):426-32.
doi: 10.1002/j.1552-4604.1976.tb02417.x.

Absorption and biotransfomation of cholecalciferol in drug-induced osteomalacia

R T Matheson, J J Herbst, W Jubiz, J W Freston, K G Tolman

Absorption and biotransfomation of cholecalciferol in drug-induced osteomalacia

R T Matheson et al. J Clin Pharmacol. 1976 Aug-Sep.

Abstract

The gastrointestinal absorption of vitamin D3 and its biotransformation to 25-hydroxycholecalciferol was studied in patients with drug-induced osteomalacia. The mean coefficient of absorption was virtually identical in the drug-treated group (82.8%) and the control (83.8%). The biotransformation of vitamin D3 to 25-hydroxycholecalciferol was significantly accelerated (P less than 0.03) in the drug-treated group compared to the control group. These data suggest that vitamin D absorption is not significantly altered but that biotransformation of vitamin D3 to 25-hydroxycholecalciferol is accelerated in drug-induced osteomalacia.

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