Stimulation of myocardial contractility by a new cyclic nucleotide analog, 8-(benzylthio)-N6-n-butyladenosine cyclic 3',5'-phosphate (SQ 80122)
- PMID: 184129
Item in Clipboard
Stimulation of myocardial contractility by a new cyclic nucleotide analog, 8-(benzylthio)-N6-n-butyladenosine cyclic 3',5'-phosphate (SQ 80122)
J Cyclic Nucleotide Res.
1976.
Abstract
The cyclic nucleotide analog, 8-(benzylthio)-N6-n-butyladenosine cyclic 3',5'-phosphate (SQ 80122) increases contractile force of excised cat right ventricular papillary muscle and stimulates myocardial contractility in the anesthetized dog. The inotropic action of this compound is independent of catecholamines and stimulation of beta-adrenergic receptors in the heart.
Similar articles
-
Effect of dibutyryl cyclic AMP on myocardial performance in vivo.Recent Adv Stud Cardiac Struct Metab. 1973;3:251-9. Recent Adv Stud Cardiac Struct Metab. 1973. PMID: 4377598 No abstract available.
-
Cardiac and metabolic effects of dibutyryl cyclic AMP in the intact dog heart and the isolated perfused rat heart.Recent Adv Stud Cardiac Struct Metab. 1973;3:233-50. Recent Adv Stud Cardiac Struct Metab. 1973. PMID: 4377597 No abstract available.
-
C-type natriuretic peptide increases myocardial contractility and sinus rate mediated by guanylyl cyclase-linked natriuretic peptide receptors in isolated, blood-perfused dog heart preparations.J Pharmacol Exp Ther. 1998 Jul;286(1):70-6. J Pharmacol Exp Ther. 1998. PMID: 9655843
-
Cyclic AMP and contractile activity in heart.Adv Cyclic Nucleotide Res. 1977;8:363-420. Adv Cyclic Nucleotide Res. 1977. PMID: 21550 Review. No abstract available.
-
Reserpine-induced supersensitivity to the cardiac effects of agonists.Life Sci. 1979 Feb 5;24(6):473-80. doi: 10.1016/0024-3205(79)90167-x. Life Sci. 1979. PMID: 219312 Review. No abstract available.
Cited by
-
The effects of adenosine- and guanosine 3',5'-phosphoric acid benzyl esters on guinea-pig ventricular myocardium.Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(2):103-11. doi: 10.1007/BF00500274. Naunyn Schmiedebergs Arch Pharmacol. 1979. PMID: 93704 No abstract available.
-
New mechanisms for positive inotropic agents: focus on the discovery and development of imazodan.Cardiovasc Drugs Ther. 1989 Mar;3(1):29-42. doi: 10.1007/BF01881527. Cardiovasc Drugs Ther. 1989. PMID: 2487522 Review.
-
Inotropic and chronotropic effects of N6-substituted derivatives of cyclic AMP as assessed in guinea-pig isolated right atria and papillary muscle.Br J Pharmacol. 1989 Jun;97(2):371-6. doi: 10.1111/j.1476-5381.1989.tb11963.x. Br J Pharmacol. 1989. PMID: 2547473 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Miscellaneous