Quantifying collagen in mouse kidneys
- PMID: 18414435
- DOI: 10.1038/ki.2008.70
Quantifying collagen in mouse kidneys
Abstract
Identification of genes underlying quantitative trait loci (QTLs) represents a formidable task. Recent advances in the annotation of the mouse genome and the availability of newly developed mouse strains should boost gene discovery. Kato and colleagues report the localization of a QTL for collagen type I deposition in kidneys on mouse chromosome 2, representing the first step for the identification of a gene involved in interstitial fibrosis, an important pathway in progression to end-stage renal failure in many kidney disorders.
Comment on
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Mapping quantitative trait loci for proteinuria-induced renal collagen deposition.Kidney Int. 2008 May;73(9):1017-23. doi: 10.1038/KI.2008.7. Epub 2008 Feb 27. Kidney Int. 2008. PMID: 18305463
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