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Comment
. 2008 May;73(9):987-9.
doi: 10.1038/ki.2008.70.

Quantifying collagen in mouse kidneys

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Quantifying collagen in mouse kidneys

S Sanna-Cherchi. Kidney Int. 2008 May.
Free article

Abstract

Identification of genes underlying quantitative trait loci (QTLs) represents a formidable task. Recent advances in the annotation of the mouse genome and the availability of newly developed mouse strains should boost gene discovery. Kato and colleagues report the localization of a QTL for collagen type I deposition in kidneys on mouse chromosome 2, representing the first step for the identification of a gene involved in interstitial fibrosis, an important pathway in progression to end-stage renal failure in many kidney disorders.

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