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Clinical Trial
. 2008 Apr 21;14(15):2388-93.
doi: 10.3748/wjg.14.2388.

Primary gastric mucosa associated lymphoid tissue lymphoma: clinical data predicted treatment outcome

Milena Todorovic  1 , Bela Balint, Miodrag Jevtic, Nada Suvajdzic, Amela Ceric, Dragana Stamatovic, Olivera Markovic, Maja Perunicic, Slobodan Marjanovic, Miodrag Krstic
Affiliations
Clinical Trial

Primary gastric mucosa associated lymphoid tissue lymphoma: clinical data predicted treatment outcome

Milena Todorovic et al. World J Gastroenterol. .

Abstract

Aim: To determine clinical characteristics and treatment outcome of gastric lymphoma after chemotherapy and immuno-chemotherapy.

Methods: Thirty four patients with primary gastric mucosa associated lymphoid tissue (MALT) lymphoma (Ann Arbor stages I to IV) were enrolled. All had upper gastric endoscopy, abdominal ultrasonography, CT and H pylori status assessment (histology and serology). After anti-H pylori treatment and initial chemotherapy, patients were re-examined every 4 mo.

Results: Histological regression of the lymphoma was complete in 22/34 (64.7%) and partial in 9 (26.5%) patients. Median follow up time for these 31 responders was 60 mo (range 48-120). No regression was noted in 3 patients. Among the 25 (73.5%) H pylori positive patients, the eradication rate was 100%.

Conclusion: Using univariate analysis, predictive factors for overall survival were international prognostic index (IPI) score, hemoglobin level, erythrocyte sedimentation rate (ESR), and platelet numbers (P < 0.005). In addition to this, Cox proportion hazard model differentiate IPI score, ESR, and platelets as predictors of survival.

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Figures

Figure 1
Figure 1
Bone marrow pathohistology in gastric MALT lymphoma patients (HE, × 100). Paratrabecular nodal lymphoid BM infiltration with neoplastic cells.
Figure 2
Figure 2
Immunohistochemistry of CD20 antigen expression in bone marrow biopsy (× 200). Nodal lymphoid BM infiltration with CD20+ in lymphoma cells.
Figure 3
Figure 3
Distribution of IPI values in gastric MALT lymphoma patients. IPI score was a highly significant (P < 0.01) prognostic factor for overall survival of patients.
Figure 4
Figure 4
Kaplan-Meir curve of cumulative survival probability in gastric MALT lymphoma patients. Cumulative survival probability was high in the following period with low rate of death.
See this image and copyright information in PMC

References

    1. Wotherspoon AC, Doglioni C, Isaacson PG. Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): a multifocal disease. Histopathology. 1992;20:29–34. - PubMed
    1. Manson SD. Mucosa-associated lymphoid tissue (MALT) lymphoma. Semin Oncol Nurs. 2006;22:73–79. - PubMed
    1. Spencer J, Finn T, Pulford KA, Mason DY, Isaacson PG. The human gut contains a novel population of B lymphocytes which resemble marginal zone cells. Clin Exp Immunol. 1985;62:607–612. - PMC - PubMed
    1. Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A. T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia. 2005;19:652–658. - PubMed
    1. Ye H, Liu H, Attygalle A, Wotherspoon AC, Nicholson AG, Charlotte F, Leblond V, Speight P, Goodlad J, Lavergne-Slove A, et al. Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma. Blood. 2003;102:1012–1018. - PubMed

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