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Randomized Controlled Trial
. 2008 Jun;22(1):13-21.
doi: 10.1007/s10840-008-9212-7. Epub 2008 Apr 17.

Pulmonary vein isolation using segmental versus electroanatomical circumferential ablation for paroxysmal atrial fibrillation: over 3-year results of a prospective randomized study

Martin Fiala  1 , Jan Chovancík, Renáta Nevralová, Radek Neuwirth, Otakar Jiravský, Igor Nykl, Libor Sknouril, Miloslav Dorda, Jaroslav Januska, Marian Branny
Affiliations
Randomized Controlled Trial

Pulmonary vein isolation using segmental versus electroanatomical circumferential ablation for paroxysmal atrial fibrillation: over 3-year results of a prospective randomized study

Martin Fiala et al. J Interv Card Electrophysiol. 2008 Jun.

Abstract

Purpose: We tested the hypothesis that electroanatomic pulmonary vein (PV) antra encircling for the PV isolation will improve the outcome in treatment of paroxysmal atrial fibrillation (PAF), compared with segmental PV isolation.

Methods: Fifty-four patients underwent segmental PV isolation (group 1) and 56 patients circumferential PV isolation (group 2) for symptomatic PAF in a randomized study.

Results: Following single ablation procedure, at the 48 +/- 8 month follow-up, 30 (56%) and 32 (57%) patients in groups 1 and 2 remained free of arrhythmia (P = 0.41). After repeat ablation, 43 (80%) and 45 (80%) patients in groups 1 and 2 were free of arrhythmia without antiarrhythmic drugs (AADs); 48 (89%) and 51 (91%) patients in groups 1 and 2 did not have arrhythmia recurrences without or with AADs.

Conclusion: This study demonstrates no advantage in long-term arrhythmia-free clinical outcome after circumferential PV isolation in patients with frequent PAF.

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