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Comment
. 2008 Apr;15(4):305-6.
doi: 10.1016/j.chembiol.2008.03.011.

PAK'n it in: identification of a selective PAK inhibitor

Gary M Bokoch  1
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Comment

PAK'n it in: identification of a selective PAK inhibitor

Gary M Bokoch. Chem Biol. 2008 Apr.

Abstract

p21-activated kinases are important signaling kinases for which no specific chemical inhibitors are known. In this issue of Chemistry & Biology, Deacon et al. target allosteric transitions undergone during PAK activation to identify a selective inhibitor (Deacon et al., 2008).

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