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Comment
. 2008 Apr;15(4):307-8.
doi: 10.1016/j.chembiol.2008.03.009.

Sweetly expanding enzymatic glycodiversification

David L Jakeman  1
Affiliations
Comment

Sweetly expanding enzymatic glycodiversification

David L Jakeman. Chem Biol. 2008 Apr.

Abstract

Directed evolution is a powerful tool to modify substrate specificity for a wide array of enzyme catalysts. In this issue of Chemistry & Biology, Thorson and coworkers use directed evolution to increase the catalytic proficiency of a model glycosyltransferase, OleD, 300-fold for a nonphysiological substrate (Williams et al., 2008).

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