Comment
doi: 10.1016/j.chembiol.2008.04.001.
The tail of mycolic acids
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- PMID: 18420136
- DOI: 10.1016/j.chembiol.2008.04.001
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Comment
The tail of mycolic acids
Chem Biol.
2008 Apr.
Abstract
The FabH enzyme from M. tuberculosis binds the acyl tail of large substrates at the end of a buried hydrophobic tunnel. Sachdeva et al. (2008) use reactive chemical probes and X-ray crystallography to show that substrates can bind to an open state of FabH without threading through the tunnel.
Comment on
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In situ observation of protein phosphorylation by high-resolution NMR spectroscopy.Nat Struct Mol Biol. 2008 Mar;15(3):321-9. doi: 10.1038/nsmb.1395. Epub 2008 Feb 24. Nat Struct Mol Biol. 2008. PMID: 18297086
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Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.Chem Biol. 2008 Apr;15(4):402-12. doi: 10.1016/j.chembiol.2008.03.007. Chem Biol. 2008. PMID: 18420147
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