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Clinical Trial
. 2008 Sep;17(6):531-4.
doi: 10.1016/j.seizure.2008.02.001. Epub 2008 Apr 16.

Lamotrigine and catamenial epilepsy

Ronit Gilad  1 , Menachem Sadeh, Abraham Rapoport, Ron Dabby, Yair Lampl
Affiliations
Free article
Clinical Trial

Lamotrigine and catamenial epilepsy

Ronit Gilad et al. Seizure. 2008 Sep.
Free article

Abstract

Catamenial epilepsy (CE) is characterized by epileptic seizures in the female occurring rhythmatically with the menstrual cycle. Hormonal mechanisms have been proposed as a cause of this epileptic form. Few reports about the efficacy of anti-epileptic drugs (AEDs) have been published. We studied prospectively women with CE who were treated with lamotrigine (LTG) for a period of 3 months in order to evaluate its efficacy, measuring the progesterone levels before and after LTG at the same time. LTG seemed to be efficacious in 66% of women, meaning the disappearance of seizures or reduction of 50% or more of the number of seizures. The reported side effects were few and mild, and the drug was well tolerated. Serum progesterone levels were found to rise during LTG treatment.

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