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Review
. 2008 May 7;6(9):1527-34.
doi: 10.1039/b800698a. Epub 2008 Mar 19.

The synthesis of enantiomerically pure [2.2]paracyclophane derivatives

Affiliations
Review

The synthesis of enantiomerically pure [2.2]paracyclophane derivatives

Gareth J Rowlands. Org Biomol Chem. .

Abstract

[2.2]Paracyclophane is a fascinating molecule that offers great potential in a wide range of chemical disciplines. Currently, the synthesis of the majority of enantiomerically pure [2.2]paracyclophane derivatives is based on the resolution of a small number of starting materials or individual resolution procedures are developed for each new compound. The development of more general routes to these valuable compounds via the resolution of a common intermediate is discussed. Ultimately, it would be preferable to synthesise these valuable compounds without recourse to resolution and ideas for this rewarding goal are postulated.

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