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. 2008 May 7;6(9):1577-86.
doi: 10.1039/b801631n. Epub 2008 Mar 12.

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Marcus Baumann  1 , Ian R Baxendale, Steven V Ley, Nikzad Nikbin, Christopher D Smith, Jason P Tierney
Affiliations

A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Marcus Baumann et al. Org Biomol Chem. .

Abstract

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

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