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. 2008 Jun;31(3):189-97.
doi: 10.1007/s10753-008-9064-4. Epub 2008 Apr 18.

Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1beta levels in airway and lung from rat subjected to LPS-induced inflammation

F Aimbire  1 , A P Ligeiro de Oliveira, R Albertini, J C Corrêa, C B Ladeira de Campos, J P Lyon, J A Silva Jr, M S Costa
Affiliations

Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1beta levels in airway and lung from rat subjected to LPS-induced inflammation

F Aimbire et al. Inflammation. 2008 Jun.

Abstract

Background and objective: Low level laser therapy (LLLT) is a known anti-inflammatory therapy. Herein we studied the effect of LLLT on lung permeability and the IL-1beta level in LPS-induced pulmonary inflammation. STUDY DESIGN/METHODOLOGY: Rats were divided into 12 groups (n = 7 for each group). Lung permeability was measured by quantifying extravasated albumin concentration in lung homogenate, inflammatory cells influx was determined by myeloperoxidase activity, IL-1beta in BAL was determined by ELISA and IL-1beta mRNA expression in trachea was evaluated by RT-PCR. The rats were irradiated on the skin over the upper bronchus at the site of tracheotomy after LPS.

Results: LLLT attenuated lung permeability. In addition, there was reduced neutrophil influx, myeloperoxidase activity and both IL-1beta in BAL and IL-1beta mRNA expression in trachea obtained from animals subjected to LPS-induced inflammation.

Conclusion: LLLT reduced the lung permeability by a mechanism in which the IL-1beta seems to have an important role.

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