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Comment
. 2008 Apr 18;133(2):206-8.
doi: 10.1016/j.cell.2008.04.004.

O2 sensing: only skin deep?

Gregg L Semenza  1
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Free article
Comment

O2 sensing: only skin deep?

Gregg L Semenza. Cell. .
Free article

Abstract

The transcription factor HIF-1 mediates adaptive responses to hypoxia, and its activity is negatively regulated by O2-dependent binding of the von Hippel-Lindau (VHL) protein. In this issue, Boutin et al. (2008) use conditional knockout mice to demonstrate that sensing of O2 by keratinocytes in the epidermis leads to alterations in cutaneous blood flow that affect the production of the hormone erythropoietin, thereby modulating red blood cell production and the O2-carrying capacity of blood.

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  • Epidermal sensing of oxygen is essential for systemic hypoxic response.
    Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. Boutin AT, et al. Cell. 2008 Apr 18;133(2):223-34. doi: 10.1016/j.cell.2008.02.038. Cell. 2008. PMID: 18423195 Free PMC article.

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